OAR 333-016-0020
Testing Procedures for Hazardous Substances


Method of testing toxic substances. The method of testing the toxic substances defined in OAR 333-016-0005 (Definitions)(5)(c) and (6)(c) is as follows:

(1)

Acute dermal toxicity (single exposure). In the acute exposures the agent is held in contact with the skin by means of a sleeve for periods varying up to 24 hours. The sleeve, made of rubber dam or other impervious material, is so constructed that the ends are reinforced with additional strips and should fit snugly around the trunk of the animal. The ends of the sleeve are tucked, permitting the central portion to “balloon” and furnish a reservoir for the dose. The reservoir must have sufficient capacity to contain the dose without pressure. In the following table are given the dimensions of sleeves and the approximate body surface exposed to the test substance. The sleeves may vary in size to accommodate smaller or larger subjects. In the testing of unctuous materials that adhere readily to the skin, mesh wire screen may be employed instead of the sleeve. The screen is padded and raised approximately two centimeters from the exposed skin. In the case of dry powder preparations, the skin and substance are moistened with physiological saline prior to exposure. The sleeve is then slipped over the gauze which holds the dose applied to the skin. In the case of finely divided powders, the measured dose is evenly distributed on cotton gauze, which is then secured to the area of exposure. (See Table 1.)

(2)

Preparation of test animals. The animals are prepared by clipping the skin of the trunk free of hair. Approximately one-half of the animals are further prepared by making epidermal abrasions every 2 centimeters or 3 centimeters longitudinally over the area of exposure. The abrasions are sufficiently deep to penetrate the stratum corneum (horny layer of the epidermis), but not to disturb the derma — that is, not to obtain bleeding.

(3)

Procedures for testing. The sleeve is slipped onto the animal which is then placed in a comfortable but immobilized position in a multiple animal holder. Selected doses of liquids and solutions are introduced under the sleeve. If there is slight leakage from the sleeve which may occur during the first few hours of exposure, it is collected and reapplied. Dosage levels are adjusted in subsequent exposures (if necessary) to enable a calculation of a dose that would be fatal to 50 percent of the animals. This can be determined from mortality ratios obtained at various doses employed. At the end of 24 hours the sleeves or screens are removed, the volume of unabsorbed material, if any, is measured, and the skin reactions are noted. The subjects are cleaned by thorough wiping, observed for gross symptoms of poisoning, and then observed for two weeks.
[ED. NOTE: Tables referenced are available from the agency.]

Source: Rule 333-016-0020 — Testing Procedures for Hazardous Substances, https://secure.­sos.­state.­or.­us/oard/view.­action?ruleNumber=333-016-0020.

333–016–0005
Definitions
333–016–0010
Human Experience with Hazardous Substances
333–016–0015
Hazardous Mixtures
333–016–0020
Testing Procedures for Hazardous Substances
333–016–0025
Method of Testing Primary Irritant Substances
333–016–0030
Test for Eye Irritants
333–016–0035
Tentative Method of Test for Flashpoint of Volatile Flammable Materials by Tagliabue Open-Cup Apparatus
333–016–0040
Method for Determining Extremely Flammable and Flammable Solids
333–016–0045
Method for Determining Extremely Flammable and Flammable Contents of Self-Pressurized Containers
333–016–0050
Method for Determining Flashpoint of Extremely Flammable Contents of Self-Pressurized Containers
333–016–0055
Method for Determining the Sound Pressure Level Produced by Toy Caps
333–016–0056
Test Methods for Simulating Use and Abuse, Toys, Games, and Other Articles Intended for Use by Children
333–016–0057
Test Methods for Simulating Use and Abuse of Toys and Other Articles Intended for Children 18 Months of Age or Less
333–016–0058
Test Methods for Simulating Use and Abuse of Toys and Other Articles Intended for Children Over 18 But not Over 36 Months of Age
333–016–0059
Test Methods for Simulating Use and Abuse of Toys and Other Articles Intended for Children Over 36 But Not Over 96 Months of Age
333–016–0060
Products Declared to be Hazardous Substances Under ORS 453.055(1)
333–016–0065
Products Requiring Special Labeling Under ORS 453.055(2)
333–016–0070
Labeling of Fire Extinguishers
333–016–0075
Banned Hazardous Substances
333–016–0077
Pointed Objects in Food Items of Particular Appeal to Children
333–016–0080
Toys and Other Articles Intended for Use by Children
333–016–0082
Repurchase of Banned Hazardous Substances
333–016–0085
Exemptions for Foods, Drugs, Cosmetics, and Fuels
333–016–0090
Exemption from Full Labeling and Other Requirements
333–016–0095
Exemptions for Small Packages, Minor Hazards, and Special Circumstances
333–016–0100
Exemption for Unlabeled Containers
333–016–0105
Exemptions from Classification as Banned Hazardous Substances
333–016–0110
Labeling of Toys, Including Games
333–016–0115
Labeling Requirements, Placement, Conspicuousness, Contrast
333–016–0120
Deceptive Use of Disclaimers
333–016–0125
Condensation of Label Information
333–016–0130
Labeling Requirements for Accompanying Literature
333–016–0135
Substances Determined to be “Special Hazards” (e.g., to children)
333–016–0140
Substances with Multiple Hazards or Other Special Hazards
333–016–0145
For the Following Substances and at the Following Concentrations, the Word “Poison” Is Necessary Instead of Any Signal Word
333–016–0150
Self-Pressurized Containers
333–016–0155
Methyl Alcohol-Base Radiator Antifreeze
333–016–0160
Ethylene Glycol-Base Radiator Antifreeze
333–016–0165
Extremely Flammable Contact Adhesives
333–016–0170
Procedural Rules
333–016–0175
Prohibited Acts and Penalties
333–016–0180
Guaranty
333–016–0185
Examinations and Investigations
333–016–0190
“Administrator” Intended to Include “State Public Health Officer”
333–016–2001
Toxic Free Kids Program
333–016–2010
Definitions
333–016–2020
Chemicals of High Concern to Children
333–016–2030
Modifications to the List of High Priority Chemicals of Concern for Children’s Health
333–016–2035
Manufacturer Disclosure of High Priority Chemicals of Concern for Children’s Health Used in Children’s Products: Practical Quantification Limits
333–016–2060
Notification Requirements
333–016–2065
Formal Communications Regarding Toxic Free Kids
333–016–2070
Exemptions from Notice Requirement
333–016–2080
Fees
333–016–3010
Removal or Substitution of High Priority Chemicals
333–016–3015
Exemptions from Removal or Substitution Requirements
333–016–3020
Requirements for Chemical Substitution
333–016–3030
Hazard Assessment for Substitute Chemicals
333–016–3040
Waiver from Removal or Substitution Requirement
333–016–3050
Quantitative Exposure Assessment
333–016–3060
Alternatives Assessment
333–016–3070
Trade Secrets
333–016–3080
Enforcement and Civil Penalties
Last Updated

Jun. 8, 2021

Rule 333-016-0020’s source at or​.us